FW: Physics Talk 5:30 Aspen Time Tonight

 

The Evolutionary “Design” of Protein Machines

 

 

 

 

2020 Heinz R. Pagels Physics Talks

Please join us LIVE ONLINE TONIGHT

5:30 Aspen time (11:30 UTC) followed by an interactive Q&A

 

 

Rama Ranganathan

University of Chicago

 

The Evolutionary “Design” of Protein Machines

 

Proteins are the nanoscale machines in cells that carry out nearly all of the functions necessary for life. Examples include antibodies that can bind to specific targets with great selectivity, enzymes that catalyze complex chemical reactions, and signaling molecules that process and transmit information about the external world. We call them “machines” because just like high-performance machines in our ordinary experience, they do their job through cycles of motions that seem finely tuned for their biological functions. But unlike man-made machines, proteins are evolved materials, built through a process that we do not yet understand and with designs for which we do not yet have good models. In this talk, I will present our understanding of the evolutionary “design” of proteins and will discuss both fundamental and practical insights that have emerged. Ultimately, the goals are to explain exactly what kind of machines proteins are, how they work, and why they are built the way they are through the process of evolution. 

 

Rama Ranganathan’s research has focused on understanding the basic principles of structure, function, and evolution in biological systems, with a particular emphasis on the atomic and cellular scale. His work has led to new models for the architecture of natural proteins and new experimental tools for studying the physics and evolution of proteins and cellular systems.

 

Professor Rangansthan leads the UChicago Center for Physics of Evolving Systems and is the director of BioCARS beamline, which is a national user facility for structural biology located at the Advanced Photon Source at Argonne National Laboratory. He is also a member of the Institute for Molecular Engineering.

 

In 2016, Prof. Ranganathan received the Transformative Research Award from the National Institutes of Health Common Fund. He has also been honored with the Edith and Peter O’Donnell Award for Basic Science from the Academy of Medicine, Engineering, and Science of Texas and the Glenn Award for Research.

 

For additional information on Rama Ranganathan’s research see:

 

Introducer and Co-host: Michael Brenner, Harvard University

 

 

 

Join us next Thursday for “Giant Black Holes Devouring Stars:

Extreme Cosmic Events Illuminating Black Hole Spacetimes”

with Lixin (Jane) Dai, University of Hong Kong

 

Aspen Center for Physics | 970-925-2585 | patty@aspenphys.org

 

 

 

 

Connect with us

 

Talks will be recorded and posted on our YouTube channel.

 

Aspen Center for Physics | 700 West Gillespie St., Aspen, CO 81611

 

The Roylab coronavirus map is back

 

We can see total cases for the U.S. again.

 

Ugh.  We can see the curve of the original spread, the slight tapering off for the extended lockdown, and the rise for the reopening.  I wonder what’s next.  What’s the next big thing?  This rise in cases is as steep as we’ve ever seen.  Will it continue up indefinitely?  Will we start wearing masks enough to moderate the slope again?  Will we do something dramatic and arrest the growth?  Today is the day coronavirus reporting is restructured to go through Washington instead of the CDC.  Will what we see next even be true?

 

Purple Martins

 

 

At home in the condo.

 

The kids all grown up, all the martins will be leaving the homestead soon.

 

They’re pretty much eastern birds.

 

Summer in the U.S. and Canada.  Winter in South America.  A solid plan.

 

I’ve been thinking

 

All those years ago.  Who knows how many bad things President Nixon did?  He did enough that he resigned before the impeachment process completed.  The story of his misdeeds might have continued on, but we have a long-standing tradition in the United States not to go after the previous president and put them in jail.  That would be a bad precedent to set; where that becomes the norm.  So not surprising that a month after Nixon resigned, President Ford, in the national interest, granted him a full, free, and absolute pardon for any crimes he committed while in office.  That was a disappointment for those that wanted the full story about everything Nixon had done; who wanted to teach him a lesson and set an example for others; but it was probably a wise decision to try to put an end to the frenzy and move on.

 

So here we are now, with it seems a scandal a day for the current president.  There are so many questions about why he does the things he does.  He talks so much about his finances but goes to such extremes to keep them private.  So much of what he says and does is inexplicable.  We only know what he says, we never know the substance behind what he’s saying, so we wonder.  Is he just that odd, or is he somehow criminal or beholden? 

 

If a person under such scrutiny as the current president, did illegal things in their life or in their presidency, they’ll likely be exposed eventually.  Presidents can’t be charged with crimes while they’re in office, but of course once they’re out of office that protection evaporates.  Roger Stone begged for a pardon and got it from this president because he didn’t “flip” on him.  That’s an interesting way to phrase it because it’s not possible to “flip” on someone if they didn’t do something wrong in the first place.  There could be inculpatory evidence that is classified for now but will eventually be declassified and the truth be known.  Perhaps there is no substance to all the suspicions about the behaviors of this president and it’s all just noise, but wouldn’t it be ironic if this president, who so disparages presidents who came before and some that may come after, and regularly hurls threats of prosecution; wouldn’t it be ironic indeed, that if once out of office, crimes of this president come to light and prosecutions are begun, it falls to some successor president, in the interest of the public good, to grant him a full, free, and absolute pardon of any and all crimes committed while in office?